2 edition of Verbal working memory in children with congenital hypothyroidism. found in the catalog.
Verbal working memory in children with congenital hypothyroidism.
Sandra Lorraine Hepworth
Written in English
Working memory is a cognitive system comprised of both short-term memory and controlled attention components. Because the working memory system is critical in many other cognitive abilities, academic success in childhood is dependent on adequate working memory functioning. Indeed children with attention deficit hyperactivity disorder (ADHD), who demonstrate working memory deficits, are at high risk for underachievement. In ADHD, the working memory deficit is believed to reflect primarily a deficit in controlled attention. However, working memory deficits can also arise from deficits in short-term memory. Research has suggested that children with congenital hypothyroidism (CH) have short-term memory difficulties. Furthermore, like children with ADHD, children with CH are at risk for underachievement. Therefore, it was hypothesized that children with CH would also show working memory difficulties reflecting problems with short-term memory.Children with CH, children with ADHD, and a group of typically developing children were compared on two computerized working memory tasks, the n-Back task and the Item Recognition task. Both tasks were developed to manipulate the short-term memory and controlled attention demands of working memory. No Group effects or interactions were found on the n-Back task. However, on the Item Recognition task, the ADHD group was outperformed by the Control group, although this difference was not specifically driven by the controlled attention component. Furthermore, although the CH group did not differ from either the ADHD or the Control group overall, females with CH did show a greater decrement in performance with increasing short-term memory load compared to females in the control group. These results indicate that although children with CH may not have working memory deficits per se, females with CH may have difficulty with the short-term memory component of working memory. Functional independence of the short-term memory and controlled attention components of working memory was not observed, but the findings provide some direction for further research regarding this issue.
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Congenital hypothyroidism occurs in approximately one per to live births (Rastog et al, ). Congenital hypothyroidism is diagnosed by measuring serum TSH and either free T4 or total T4 combined with T3 resin uptake. Conversely, in a prospective study of 20 children with mild SH, 6 months of L-T4 treatment was associated with a significant improvement in visual memory, verbal memory, and verbal recall scores as well as in N2 latency at ERPs, suggesting that L-T4 might have beneficial effects on executive functions.
Prematurity is associated with impairments in multiple measures of both verbal and spatial working memory when tested in children or adolescents, 32, 33 Greater working memory impairments were present when tested by reverse digit span in school-aged children born prematurely with lower birth weights. 34 Using diffuse tensor imaging, Shany. Abstract. Background: The ability to detect the spatial characteristics of objects and to rotate them mentally is frequently impaired in early treated congenital hypothyroidism (CH) : To explore the neural substrate of the visuospatial difficulty in children with CH, we studied 15 children with CH (8–10 years) and 13 age-matched control children with functional magnetic.
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In two recent studies (43, 44*), subjects with subclinical hypothyroidism had impaired verbal and spatial working memory and abnormal fMRI results in frontal brain areas. Some subjects were treated with L-T4 for 6 months, at which point verbal and spatial working memory and fMRI findings by: Present findings showed that relative to controls, children and adolescents with CH exhibit poorer recall on verbal but not visuospatial memory tasks and an increased number of everyday memory problems, especially in everyday spatial memory.
The CH group also had smaller hippocampi than controls, particularly on the left by: While pretreatment verbal memory (VM) and verbal recall (VR) scores of the SH group were significantly lower than those of the control group (p= andrespectively), no significant differences between the post-treatment and control groups were found in these scores after 6 months of L-T4 by: 7.
In % of children, the congenital malformations of other organs were found, mainly in patients with congenital hypothyroidism caused by thyroid dystopia.
View Show abstract. Children with congenital hypothyroidism (CH) identified by newborn screening and treated early in life have normal intelligence but demonstrate residual cognitive deficits. Verbal working memory (VWM) is responsible for temporarily storing verbalizable information, such as letters, words, numbers, or nameable objects.
Baddeley () proposed an influential framework in which the VWM includes a phonological loop. This phonological loop consists of two subcomponents: (1) a passive storage process that lasts 1–2 s and (2) an active articulatory.
The Digit Span is used to evaluate verbal working memory, immediate recall, and the ability to hold, retain, and manipulate new verbal information (Groth-Marnat and Baker, ), which is a subtest of WISC-R (Lin and Zhang, ).
Participants are read a string of numbers and asked to repeat them in the same order and backward. natal neurodevelopment.
Despite early diagnosis and treatment of congenital hypothyroidism (CH), difficulties with language, hearing, memory and motor function persist for some children. However, comprehensive data about hearing, language and communication function in children with CH are not widely available.
Neuropsychological significance of variations in patterns of academic performance: Verbal and visual-spatial abilities. Journal of Abnormal Child Psychology, 6(1), Mammarella, IC, & Cornoldi, C ().
An analysis of the criteria used to diagnose children with Nonverbal Learning Disability (NLD). Child Neuropsychology, 20(3), INTRODUCTION. The known effects of thyroid hormones on functions of the central nervous system include effects on intelligence, emotional status, behavior and cognitive functions (1,2).Hypothyroidism is a metabolic condition that can lead to cognitive and behavioral deficits in children and adolescents (3,4).Current data suggest that early diagnosis and treatment of hypothyroidism.
memory. No significant differences were found between both groups in the verbal area. Conclusions. Children with congenital hypothyroidism and without mental disability had mild cognitive deficits, which should be taken into account for a comprehensive patient care.
Key words: congenital hypothyroidism, cognitive. Hepworth's 10 research works with citations and reads, including: Word and Face Recognition in Children with Congenital Hypothyroidism: An Event-Related Potential Study. Children with congenital hypothyroidism have difficulties with episodic memory and abnormalities in hippocampal structure, suggesting deficient hippocampal functioning.
show deficits in verbal. Verbal Working Memory In Children With Congenital Hypothyroidism Microform Author: Sandra Lorraine Hepworth ISBN: Working memory performance does not show a sex difference in typically developing children (Alloway et al., ), and there was no sex difference in working memory performance in our study.
It is therefore unlikely that the CAH-related differences we observed in working memory performance were caused by androgen exposure.
Recent studies have demonstrated impaired verbal memory in patients with a primary form of hypothyroidism 8] and decrement in delayed recall with a specific deficit in the retrieval process. Background. A strong relationship exits between thyroid hormone and brain development.
Thyroid hormone therapy has a significant long-term impact on child behavior, locomotor ability, speech, hearing and cognition in children with congenital hypothyroidism .In addition, behavioral problems were a common finding in children and adults with congenital hypothyroidism.
Patients are also at risk for endocrine/autoimmune disorders such as diabetes 34 and hypothyroidism, which is present in about 10% of children and 50% of adults with Turner syndrome.
While most individuals with Turner syndrome are of normal intelligence, there is an association with nonverbal learning disorder 35 and therefore evaluation with. children with congenital hypothyroidism detected by neonatal screen and treated early in life showed a general-ized learning disorder .
Simons et al. concluded that children with severe congenital hypothyroidism treated early at mean age of days (19–57 days) showed defi-cits in IQ score at age 3 and 5 year of age and these deficits.
CH= Congenital Hypothyroidism. CMS=Children’s Memory Scale. DG=Dentate Gyrus. EPSP= Excitatory Post-Synaptic Potential. fMRI=Functional Magnetic Resonance Imaging. IP=Intact Pairs. IQ=Intelligence Quotient. LTP=Long-Term Potentiation.
MARINA-Masks for Region of Interest Analysis. MTL=Medial Temporal Lobe. Introduction. Memory is an important part of cognition and is inter-related with executive function skills.
Memory deficits have been reported in up to 57% of adolescents with congenital heart disease (CHD) who have undergone surgical palliation (1–5).The mechanisms contributing to memory or neurocognitive deficits are multifactorial and are likely to include .The children’s poor ability to recall single syllable words in relation to non-words is a clinical indicator of their difficulties in verbal short-term memory.
However, the children with hearing-impairment do not display generalized processing difficulties and indeed demonstrate strengths in visual working memory.La Biblioteca Virtual en Salud es una colección de fuentes de información científica y técnica en salud organizada y almacenada en formato electrónico en la Región de América Latina y el Caribe, accesible de forma universal en Internet de modo compatible con .